Why Is Gain Of Function Research Making News Amidst The Pandemic?

Why Is Gain Of Function Research Making News Amidst The Pandemic?

Since the onset of Covid-19 pandemic, the scientific community is debating regarding the transparency of virus research. This is specifically regarding the federally funded research that involves making pathogens more deadly or more transmissible for research purposes. But is it worth it if it can risk the public health in case it escapes the lab environment? How do we make it more ethical? Let’s first understand the basics of Gain of Function research for this.

Crux of the Matter

What Is Gain Of Function?
GoF is a study that involves creation of pathogens with additional functionalities than occur in nature. This could even lead to creation of pathogens that are more transmissible and deadlier.

Why Would We Do That?
It is performed to understand the way in which a pathogen adapts to environmental pressures. This allows disease control measures to be better planned, and potential vaccines to be explored. Also research on bio-weapons and vaccines is carried out in case a malicious entity weaponises such pathogens.

Controversy With GoF
In 2012, a team worked on a paper, Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets for genetically modifying H5V1 virus by creating a strain that was airborne in ferrets. This demonstrated that it was possible for the avian influenza virus to become transmissible in air and that the strain was sensitive to certain antiviral drugs.

Research Stopped
 The possibility of an accidental or intentional malicious release of such a virus caused the US to halt funding for GoF research relating to influenza, SARS, or MERS in 2014.

Research Restarted
In 2017, National Science Advisory Board for Biosecurity concluded that very few such experiments posed a risk to public safety. So the ban was lifted and White House developed an ethical analysis white paper.

What’s In The White Paper

Transparency In Research
In such analysis, expert-panel members are not publicly available, nor are its reviews of study proposals.

We’re not trying to say the policy is wrong, we’re trying to say the policy is ambiguous

Marc Lipsitch, Harvard epidermiologist

Unknown Origins Of Covid-19
There have been theories about Covid-19 causing SARS-CoV-2 emerging as a result of Gain of Function research. That’s because the pandemic started in December 2019 in Wuhan, China, which also houses the Wuhan Institute of Virology, that conducts research on bat coronaviruses. Till date, we don’t know if Covid-19 originated in the wild or in the lab.

Curiopedia
  • The word Pathogenic came into existence in 1852 and the word Pathogen was derived from ‘Pathogenic’ during the 1880s. In Greek, the word Pathogenic means “origin of suffering“.
  • Antonie van Leeuwenhoek invented the first microscope in the 1600s. It was a single lens microscope made with a very small glass ball lens. With the help of that microscope he then rediscovered the red blood cells and Spermatozoa.
  • Fungi’s medicinal significance was discovered in 1928 by Scottish bacteriologist Alexander Fleming. Fungi can also be eaten; for example, certain mushrooms, morels, and truffles are considered epicurean delicacies, and mycoproteins (fungal proteins) obtained from the mycelia of some fungi are used to produce high-protein foods.

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